Gastric emptying of solids and liquids and gastrointestinal symptoms remain stable over time in patients with long-term type 1 and type 2 diabetes, according to a study published online Aug. 13 in Diabetes Care.
Jessica Chang, M.B.B.S., of the University of Adelaide and Royal Adelaide Hospital in Australia, and colleagues examined the natural history of gastric emptying in diabetes using data from 13 patients with diabetes (12 with type 1 and one with type 2). The participants had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function available from baseline and after 24.7 ± 1.5 years.
The researchers found no change in gastric emptying of solids or liquids, with gastric emptying at follow-up related to baseline emptying. Gastrointestinal symptoms also remained stable over time. Blood glucose concentrations were significantly lower at follow-up, and autonomic function deteriorated significantly.
”In summary, this prospective study indicates that gastric emptying in patients with long-term diabetes is relatively stable over time,” the authors write.
Abstract
A 25-Year Longitudinal Evaluation of Gastric Emptying in Diabetes
Jessica Chang, MBBS1,2,
Antonietta Russo, MMSC2,
Michelle Bound, BMEDRAD (NUCMED)2,
Christopher K. Rayner, MBBS, PHD1,2⇓,
Karen L. Jones, PHD1,2 and
Michael Horowitz, MBBS, PHD1,2
Author Affiliations
1University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
2Centre of Clinical Research Excellence in Nutritional Physiology, Interventions, and Outcomes, Adelaide, South Australia, Australia
Corresponding author: Christopher Rayner, chris.rayner@adelaide.edu.au
Abstract
OBJECTIVE To evaluate the natural history of gastric emptying in diabetes.
RESEARCH DESIGN AND METHODS Thirteen patients with diabetes (12, type 1; 1, type 2) had measurements of gastric emptying, blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and after 24.7 ± 1.5 years.
RESULTS There was no change in gastric emptying of either solids (% retention at 100 min) (baseline 58.5 ± 5% vs. follow-up 51.9 ± 8%; P = 0.35) or liquids (50% emptying time) (baseline 29.8 ± 3 min vs. follow-up 34.3 ± 6 min; P = 0.37). Gastric emptying of solid at follow-up was related to emptying at baseline (r = 0.56, P < 0.05). At follow-up, blood glucose concentrations were lower (P = 0.006), autonomic function deteriorated (P = 0.03), and gastrointestinal symptoms remained unchanged (P = 0.17).
CONCLUSIONS In unselected patients with diabetes, gastric emptying appears remarkably stable over 25 years.
Diab Care Aug 2012
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