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Loneliness occurs when an individual perceives that their social needs are not being met and reflects an imbalance between desired and actual social relationships.
 
The researchers conducted first ever study to investigate the experience of loneliness with later onset of type 2 diabetes. The results indicate that prolonged loneliness may influence the development of diabetes and there was a strong relationship between loneliness and the later onset of type 2 diabetes.
 
 The findings suggest that helping people form and experience positive relationships could be a useful tool in prevention strategies for type 2 diabetes. 
 
The study has been published in the journal Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]).
 
 There is a growing interest in the role of loneliness in health and previous research has associated loneliness with increased risk of death and heart disease. A fifth of adults in the UK and a third of adults in the USA report feeling lonely sometimes.
 
The study analysed data from the English Longitudinal Study Ageing on 4112 adults aged 50 years and over which was collected at several times from 2002 to 2017. At the start of data collection all participants were free of diabetes and had normal levels of blood sugar.
 
The study showed that over a period of 12 years 264 people developed type 2 diabetes. and the level of loneliness measured at the start of data collection was a significant predictor of the onset of type 2 diabetes later on in life. This relationship remained intact when accounting for smoking, alcohol, weight, level of blood glucose, high blood pressure and cardiovascular disease. The association was also independent of depression, living alone and social isolation.
 
Lead author Dr Ruth Hackett from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) King's College London said: 'The study shows a strong relationship between loneliness and the later onset of type 2 diabetes. What is particularly striking is that this relationship is robust even when factors that are important in diabetes development are taken into account such as smoking, alcohol intake and blood sugar as well as mental health factors such as depression.
 
The study also demonstrates a clear distinction between loneliness and social isolation in that isolation or living alone does not predict type 2 diabetes whereas loneliness, which is defined by a person's quality of relationships, does.
 
She continued: 'I came up with the idea for the research during UK lockdown for the COVID-19 pandemic as I became increasingly aware and interested in how loneliness may affect our health, especially as it is likely that many more people were experiencing this difficult emotion during this period.'
 
According to the study a possible biological reason behind the association between loneliness and type 2 diabetes could be the impact of constant loneliness on the biological system responsible for stress, which, over time affects the body and increases the risk for diabetes. 'If the feeling of loneliness becomes chronic,' explained Dr Hackett.
 
'Then everyday you're stimulating the stress system and over time that leads to wear and tear on your body and those negative changes in stress-related biology may be linked to type 2 diabetes development.' Another explanation for the findings could be biases in our thinking that may perpetuate the association between loneliness and diabetes as when people feel lonely, they expect people will react to them negatively which makes it more difficult to form good relationships.
 
For further reference log on to: Hackett, R.A. et al. (2020) Loneliness and type 2 diabetes incidence: findings from the English Longitudinal Study of Ageing. Diabetologia
 
https://link.springer.com/article/10.1007/s00125-020-05258-6
 

Abstract

Aims/hypothesis

Loneliness is associated with all-cause mortality and coronary heart disease. However, the prospective relationship between loneliness and type 2 diabetes onset is unclear.

Methods

We conducted a longitudinal observational population study with data on 4112 diabetes-free participants (mean age 65.02 ± 9.05) from the English Longitudinal Study of Ageing. Loneliness was assessed in 2004–2005 using the revised University of California, Los Angeles (UCLA) Loneliness Scale. Incident type 2 diabetes cases were assessed from 2006 to 2017. Associations were modelled using Cox proportional hazards regression, adjusting for potential confounders, which included cardiometabolic comorbidities.

Results

A total of 264 (6.42%) participants developed type 2 diabetes over the follow-up period. Loneliness was a significant predictor of incident type 2 diabetes (HR 1.46; 95% CI 1.15, 1.84; p = 0.002) independent of age, sex, ethnicity, wealth, smoking status, physical activity, alcohol consumption, BMI, HbA1c, hypertension and cardiovascular disease. Further analyses detected an association between loneliness and type 2 diabetes onset (HR 1.41; 95% CI 1.04, 1.90; p = 0.027), independent of depressive symptoms, living alone and social isolation. Living alone and social isolation were not significantly associated with type 2 diabetes onset.

Conclusions/interpretation

Loneliness is a risk factor for type 2 diabetes. The mechanisms underlying this relationship remain to be elucidated.

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