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This special topic collection of the June 2015 issue of Diab Care, Type 1 Diabetes at a Crossroads, includes a series of studies and a commentary focused on a wide range of issues surrounding type 1 diabetes, including: the present status of treatment methods and clinical outcomes; current concepts of pathogenesis, prediction and prevention; success and ongoing challenges of islet cell transplantation; and a pathway for advances in diabetes technology to an artificial pancreas suitable for real-world use by a large number of patients. 

“Over the recent past, Diabetes Care has reported important new information regarding the burden of diabetes, prevention and screening, as well as comprehensive discussions on new therapies,” said the journal’s editor, William T. Cefalu, MD. “However, the most impressive changes in treatment and preventive strategies have been focused on type 2 diabetes.

Our editorial team wanted to be sure readers likewise had the opportunity to learn of the latest updates from studies, opinions and perspectives in the field on advances in type 1 diabetes. This special issue allows us to do that.”

Editorial:
Type 1 Diabetes at a Crossroads!
William T. Cefalu, William V. Tamborlane, and Jay S. Skyler

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Perspectives in Care:
Current State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry
Kellee M. Miller, Nicole C. Foster, Roy W. Beck, Richard M. Bergenstal, Stephanie N. DuBose, Linda A. DiMeglio, David M. Maahs, William V. Tamborlane, for the T1D Exchange Clinic Network

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Perspectives in Care:
Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease

Mark A. Atkinson, Matthias von Herrath, Alvin C. Powers, and Michael Clare-Salzler

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Perspectives in Care:
Predicting Type 1 Diabetes Using Biomarkers

Ezio Bonifacio

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Perspectives in Care:
Prevention and Reversal of Type 1 Diabetes—Past Challenges and Future Opportunities

Jay S. Skyler

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Review Article:
Impact of Fat, Protein, and Glycemic Index on Postprandial Glucose Control in Type 1 Diabetes: Implications for Intensive Diabetes Management in the Continuous Glucose Monitoring Era
Kirstine J. Bell, Carmel E. Smart, Garry M. Steil, Jennie C. Brand-Miller, Bruce King, and Howard A. Wolpert

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Review Article:
Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1
Diabetes Complicated by Problematic Hypoglycemia
Pratik Choudhary, Michael R. Rickels, Peter A. Senior, Marie-Christine Vantyghem, Paola Maffi, Thomas W. Kay, Bart Keymeulen, Nobuya Inagaki, Frantisek Saudek, Roger Lehmann, and Bernhard J. Hering

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Perspectives in Care:
Islet Transplantation for Type 1 Diabetes, 2015: What Have We Learned From Alloislet and Autoislet Successes?

R. Paul Robertson

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Perspectives in Care:
Pathway to Artificial Pancreas Systems Revisited: Moving Downstream

Aaron Kowalski

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