– Flavonoid intake is inversely associated with the risk of type 2 diabetes, according to a large European study published online Oct. 15 in Diabetes Care. Raul Zamora-Ros, Ph.D., from the MRC Epidemiology Unit in Cambridge, U.K., and colleagues examined the correlation between dietary flavonoid and lignan intakes and the risk of type 2 diabetes development. Data were used from the European Prospective Investigation into Cancer and Nutrition-InterAct case-cohort study involving 12,403 incident cases of type 2 diabetes, and a stratified sub-cohort of 16,145 participants from among 340,234 participants in eight European countries. Country-specific validated dietary questionnaires were used at baseline. The researchers observed a trend for an inverse association between total flavonoid intake and type 2 diabetes in multivariable models (hazard ratio [HR] for the highest versus the lowest quintile, 0.90; P value trend = 0.040), but not for lignans (HR, 0.88; P value trend = 0.119). A significantly reduced risk of diabetes was seen for flavonols (HR, 0.81; P value trend = 0.020) and flavanols (HR, 0.82; P value trend = 0.012), including flavan-3-ol monomers (HR, 0.73; P value trend = 0.029). ”In conclusion, this large case-cohort study conducted in eight European countries supports a role for dietary intake of flavonoids in the prevention of type 2 diabetes in men and women,” the authors write. ”These results highlight the potential protective effect of eating a diet rich in flavonoids (a dietary pattern based on plant-based foods) on type 2 diabetes risk.”
From www HealthDay News
The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European PopulationsThe EPIC-InterAct Study
AbstractOBJECTIVE To study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations. RESEARCH DESIGN AND METHODS The European Prospective Investigation into Cancer and Nutrition-InterAct case-cohort study included 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 participants from among 340,234 participants with 3.99 million person-years of follow-up in eight European countries. At baseline, country-specific validated dietary questionnaires were used. A flavonoid and lignan food composition database was developed from the Phenol-Explorer, the U.K. Food Standards Agency, and the U.S. Department of Agriculture databases. Hazard ratios (HRs) from country-specific Prentice-weighted Cox regression models were pooled using random-effects meta-analysis. RESULTS In multivariable models, a trend for an inverse association between total flavonoid intake and type 2 diabetes was observed (HR for the highest vs. the lowest quintile, 0.90 [95% CI 0.77–1.04]; P value trend = 0.040), but not with lignans (HR 0.88 [95% CI 0.72–1.07]; P value trend = 0.119). Among flavonoid subclasses, flavonols (HR 0.81 [95% CI 0.69–0.95]; P value trend = 0.020) and flavanols (HR 0.82 [95% CI 0.68–0.99]; P value trend = 0.012), including flavan-3-ol monomers (HR 0.73 [95% CI 0.57–0.93]; P value trend = 0.029), were associated with a significantly reduced hazard of diabetes. CONCLUSIONS Prospective findings in this large European cohort demonstrate inverse associations between flavonoids, particularly flavanols and flavonols, and incident type 2 diabetes. This suggests a potential protective role of eating a diet rich in flavonoids, a dietary pattern based on plant-based foods, in the prevention of type 2 diabetes. Nyhetsinfo www red DiabetologNyt |
