Antipsychotic drugs tied to diabetes risk in children

NEW YORK (Reuters Health) – The antipsychotic drugs that are increasingly being used to treat bipolar disorder, autism and other mental disorders in children may come with an increased risk of diabetes, a new study suggests.

Previous research has linked the so-called second-generation antipsychotics to an increased risk of diabetes in adults. And there’s been some evidence that the drugs can cause weight gain in children.

The new findings, published in the journal Pediatrics, add to concerns that the medications may ultimately lead to diabetes in some kids.

Using records from three U.S. health plans, researchers found that children and teens who started on an antipsychotic had four times the risk of being diagnosed with diabetes, versus kids not using any psychiatric medication.

They developed diabetes at a rate of just over three cases per 1,000 children per year. That compared with just under 0.8 cases per 1,000 among medication-free kids.

Second-generation antipsychotics include drugs such as Risperdal, known generically as risperidone, Zyprexa (olanzapine), Seroquel (quetiapine) and Abilify (aripiprazole).

The drugs are used to treat conditions like bipolar disorder, schizophrenia and irritability and aggression in children with autism. They are also sometimes given to children with attention-deficit hyperactivity disorder (ADHD), even though there’s no research evidence to support that.

And it’s the growing use of the drugs in kids — particularly for conditions in which the benefit is unclear — that makes the potential diabetes risk concerning, according to Dr. Jonathan Mink, chief of child neurology at the University of Rochester Medical Center in New York.

”These medications can be very helpful in certain settings,” said Mink, who is also part of a pediatric advisory panel to the U.S. Food and Drug Administration. In September, the panel recommended that the agency keep monitoring the risks of weight gain and diabetes in children on antipsychotics.

Exactly why antipsychotics would lead to diabetes in some children is not clear. It’s known that they can spur weight gain, but Mink said that ”it’s hard to argue that it’s just weight gain.”

Pediatrics Nov

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