_{An Examination of Whether Diabetes Control and Treatments Are Associated With Change in Frailty Index Across 8 Years: An Ancillary Exploratory Study From the Action for Health in Diabetes}

 

Greater blood sugar control among T2DM slow biological aging by metformin or 5% weight loss. The research team describe longitudinal and cross-sectional between HbA1c and strategies for controlling T2DM with baseline levels and 8 year changes in deficit accumulation FI, a frequently used marker of biological ageing, 

 

Lower HbA1c among patients with T2DM are linked with slower biological ageing.

 

OBJECTIVE

The aim of this study was to describe cross-sectional and longitudinal associations between glycated hemoglobin (HbA_1c) levels and strategies to control type 2 diabetes with baseline levels and 8-year changes in a deficit accumulation frailty index (FI), a commonly used marker of biological aging.

RESEARCH DESIGN AND METHODS

We conducted exploratory analyses from 4,169 participants, aged 45–76 years, who were followed in the Action for Health in Diabetes (Look AHEAD) randomized controlled clinical trial, pooling data across intervention groups.

We related baseline and 8-year levels of HbA_1c with FI scores using analyses of variance and covariance. Associations between 8-year changes in FI and the use of diabetes medication classes and weight changes were assessed with control for HbA_1c levels. Inverse probability weighting was used to assess bias associated with differential follow-up.

RESULTS

Baseline and average HbA_1c levels over time of <7%, as compared with ≥8%, were associated with less increase in FI scores over 8 years (both P ≤ 0.002). A

fter adjustment for HbA_1c, use of metformin and weight loss >5% were independently associated with slower increases in frailty.

CONCLUSIONS

Lower HbA_1c levels among individuals with diabetes are associated with slower biological aging as captured by a deficit accumulation FI.

Strategies to control diabetes through weight loss or metformin use may also slow aging.

 

 

This article contains supplementary material online at https://doi.org/10.2337/figshare.21657221.

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Nyhetsinfo

www red DiabetologNytt

 

Nyhetsinfo

www red DiabetologNytt