The International Diabetes Federation (IDF) has released a Position Statement that presents the 1-hour post-load plasma glucose (1-h PG) test as a more sensitive and practical method to screen for intermediate hyperglycaemia (IH) and type 2 diabetes(T2D) in people at risk.
The Statement was prepared by an international panel* of 22 experts from 15 countries and presented at the 17th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD)in Florence, Italy and was published online in Diabetes Research and Clinical Practice.
https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(24)00073-1/abstract
• The Statement recommends the use of 1-h PG with the validated cut points of 8.6 mmol/L for IH and 11.6 mmol/L for T2D.
IH, sometimes referred to as “prediabetes,” is a state between normal glucose regulation (NGR) and T2D. It includes impaired fasting glycaemia (IFG) and impaired glucose tolerance (IGT).
Many individuals with IH as defined by current diagnostic criteria, will progress to T2D. Evidence shows that T2D can be prevented by lifestyle modification and/or medications in people with IGT diagnosed by 2-h PG during a 75-gram oral glucose tolerance test (OGTT).
• Unfortunately, many people with T2D and those with IGT remain undiagnosed if an OGTT is not employed. Given the continued rising prevalence of diabetes worldwide, a more sensitive and practical method is therefore needed to detect people with IH and T2D for early diagnosis and intervention.
A wealth of epidemiological data has confirmed the superior value of 1-h PG over fasting PG (FPG), glycated haemoglobin (HbA1c) and 2-h PG in populations of different ethnicity, sex and age.
The IDF Position Statement reviews findings that the 1-h post-load PG > 155 mg/dL (8.6 mmol/L) in those with NGR during an OGTT is highly predictive for detecting people at risk of progression to T2D, micro- and macrovascular complications, obstructive sleep apnoea, cystic fibrosis-related diabetes, metabolic dysfunction-associated steatotic liver disease, and premature death. Importantly, by using the 1-h PG cut points of 155 mg/dL (8.6 mmol/L) for diagnosing IH and 209 mg/dL (11.6 mmol/L) for diagnosing T2D, people at risk can be detected earlier than with the currently recommended glycaemic thresholds.
• Therefore, the IDF Position Statement recommends the adoption of 1-h PG with the aforementioned cut points.
Presenting the Position Statement at ATTD, Professor Michael Bergman, who co-chaired the Expert Panel with Professor Jaakko Tuomilehto, said,
“There are many people who would not be diagnosed through an HbA1c or FPG test but who would, if given an OGTT, be more likely to be detected as having IH or T2D. The 1-h PG has been found to be a more sensitive biomarker for the earlier identification of these high-risk individuals.”
The IDF Position Statement proposes the following pathway for detecting IH and T2D:
- People determined to be at high-risk for T2D through a validated screening tool (e.g. Finnish FINDRISC, ADA risk score) should undergo a 75-gram 1-h OGTT after an overnight fast.
- People with a 1-h PG value at or above 155 mg/dL (8.6 mmol/L) are considered to have IH and should be prescribed lifestyle intervention and referred to a diabetes prevention programme.
- People with a 1-h PG value at or above 209 mg/dL (11.6 mmol/L) are considered to have T2D. They should have a repeat test to confirm the diagnosis and then be referred for further evaluation and treatment.
Commenting on the Position Statement, Professor Akhtar Hussain, President of the International Diabetes Federation, said,
“The latest IDF estimates suggest that a staggering 850 million adults worldwide are affected by intermediate glycaemia. Its early detection is key to preventing or delaying the progression to diabetes and avoiding the serious and often life-threatening complications associated with the condition.
– I congratulate the Expert Panel for the work undertaken to develop this IDF Position Statement. We welcome further discussion on the use of this method to detect IH and type 2 diabetes.”
Although there are challenges inherent in implementing the 1-h OGTT, using this test after screening with a non-laboratory diabetes risk tool will help identify people at high risk of T2D earlier and contribute to reducing the global impact of diabetes, advancing global public health beyond the significant achievements in diabetes prevention studies.
The expert panel was co-chaired by Professor Michael Bergman, Professor of Medicine and Population Health at New York University Grossman School of Medicine, New York City and Professor Jaakko Tuomilehto, Professor Emeritus of Public Health, University of Helsinki, Finland, and Visiting Scientist, Finnish Institute for Health and Welfare, Helsinki, Finland. Leadership and support for this initiative were provided by Professor Akhtar Hussain, President of the International Diabetes Federation, Professor (Diabetes & Metabolic Disorder) NORD University, Bodø, Norway and Professor Antonio Ceriello IRCCS MultiMedica, Milan, Italy.
Presss release IDF
Nyhetsinfo
www red DiabetologNytt
_________________
https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(24)00073-1/abstract
International Diabetes Federation Position Statement on the 1-hour post-load plasma glucose for the diagnosis of intermediate hyperglycaemia and type 2 diabetes
- Michael Bergman
- Melania Manco
- Ilhan Satman
- Akhtar Hussain
- Antonio Ceriello
- Jaakko Tuomilehto
- Show all authors
Published:March 06, 2024DOI:https://doi.org/10.1016/j.diabres.2024.111589
Abstract
Many individuals with intermediate hyperglycaemia (IH), including impaired fasting glycaemia (IFG) and impaired glucose tolerance (IGT), as presently defined, will progress to type 2 diabetes (T2D). There is confirmatory evidence that T2D can be prevented by lifestyle modification and/or medications, in people with IGT diagnosed by 2-h plasma glucose (PG) during a 75-gram oral glucose tolerance test (OGTT). Over the last 40 years, a wealth of epidemiological data has confirmed the superior value of 1-h plasma glucose (PG) over fasting PG (FPG), glycated haemoglobin (HbA1c) and 2-h PG in populations of different ethnicity, sex and age in predicting diabetes and associated complications including death. Given the relentlessly rising prevalence of diabetes, a more sensitive, practical method is needed to detect people with IH and T2D for early prevention or treatment in the often lengthy trajectory to T2D and its complications.
The International Diabetes Federation (IDF) Position Statement reviews findings that the 1-h post-load PG ≥ 155 mg/dL (8.6 mmol/L) in people with normal glucose tolerance (NGT) during an OGTT is highly predictive for detecting progression to T2D, micro- and macrovascular complications, obstructive sleep apnoea, cystic fibrosis-related diabetes mellitus, metabolic dysfunction-associated steatotic liver disease, and mortality in individuals with risk factors. The 1-h PG of 209 mg/dL (11.6 mmol/L) is also diagnostic of T2D. Importantly, the 1-h PG cut points for diagnosing IH and T2D can be detected earlier than the recommended 2-h PG thresholds. Taken together, the 1-h PG provides an opportunity to avoid misclassification of glycaemic status if FPG or HbA1calone are used. The 1-h PG also allows early detection of high-risk people for intervention to prevent progression to T2D which will benefit the sizeable and growing population of individuals at increased risk of T2D.
Using a 1-h OGTT, subsequent to screening with a non-laboratory diabetes risk tool, and intervening early will favourably impact the global diabetes epidemic. Health services should consider developing a policy for screening for IH based on local human and technical resources. People with a 1-h PG ≥ 155 mg/dL (8.6 mmol/L) are considered to have IH and should be prescribed lifestyle intervention and referred to a diabetes prevention program. People with a 1-h PG ≥ 209 mg/dL (11.6 mmol/L) are considered to have T2D and should have a repeat test to confirm the diagnosis of T2D and then referred for further evaluation and treatment.
The substantive data presented in the Position Statement provides strong evidence for redefining current diagnostic criteria for IH and T2D by adding the 1-h PG.
See all References
-
- Sun H.
- Saeedi P.
- Karuranga S.
- Pinkepank M.
- Ogurtsova K.
- Duncan B.B.
- et al.
IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045.Diabetes Res Clin Pract.2022; 183(Epub 2021 Dec 6. Erratum in: Diabetes Res Clin Pract. 2023 Oct;204:110945. PMID: 34879977)109119https://doi.org/10.1016/j.diabres.2021.109119View in Article
-
- Jagannathan R.
- Buysschaert M.
- Medina J.L.
- Katz K.
- Musleh S.
- Dorcely B.
- et al.
The 1-h post-load plasma glucose as a novel biomarker for diagnosing dysglycemia.Acta Diabetol.2018; 55: 519-529View in Article
-
- Fiorentino T.V.
- Marini M.A.
- Succurro E.
- Andreozzi F.
- Perticone M.
- Hribal M.L.
- et al.
One-hour postload hyperglycemia: implications for prediction and prevention of type 2 diabetes.J Clin Endocrinol Metab.2018; 103: 3131-3143View in Article
-
- Bergman M.
- Abdul-Ghani M.
- DeFronzo R.A.
- Manco M.
- Sesti G.
- Fiorentino T.V.
- et al.
Review of methods for detecting glycemic disorders.Diabetes Res Clin Pract.2020; 165108233View in Article
-
- Bergman M.
The 1-hour plasma glucose: common link across the glycemic Spectrum.Front Endocrinol (Lausanne).2021; 12752329View in Article
-
- Buysschaert M.
- Bergman M.
- Valensi P.
1-h post-load plasma glucose for detecting early stages of prediabetes.Diabetes Metab.2022; 48101395View in Article
-
- Jagannathan R.
- Neves J.S.
- Dorcely B.
- Chung S.T.
- Tamura K.
- Rhee M.
- et al.
The oral glucose tolerance test: 100 years later.Diabetes Metab Syndr Obes.2020; 13: 3787-3805View in Article
-
- Bergman M.
- Manco M.
- Sesti G.
- Dankner R.
- Pareek M.
- Jagannathan R.
- et al.
Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L).Diabetes Res Clin Pract.2018; 146: 18-33View in Article
-
- Bergman M.
- Jagannathan R.
- Buysschaert M.
- Pareek M.
- Olsen M.H.
- Nilsson P.M.
- et al.
Lessons learned from the 1-hour post-load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised.Diabetes Metab Res Rev.2018; 34: e2992View in Article
-
- Bergman M.
- Jagannathan R.
- Buysschaert M.
- Medina J.L.
- Sevick M.A.
- Katz K.
- et al.
Reducing the prevalence of dysglycemia: is the time ripe to test the effectiveness of intervention in high-risk individuals with elevated 1 h post-load glucose levels?.Endocrine.2017; 55: 697-701View in Article
-
- Jagannathan R.
- Bergman M.
Use of 1-h post-load plasma glucose concentration to identify individuals at high risk of developing type 2 diabetes.Diabet Med.2017; 34: 877-878View in Article
-
- Dorcely B.
- Katz K.
- Jagannathan R.
- Chiang S.S.
- Oluwadare B.
- Goldberg I.J.
- et al.
Novel biomarkers for prediabetes, diabetes, and associated complications.Diabetes Metab Syndr Obes.2017; 10: 345-361View in Article
-
- Chan J.C.N.
- Lim L.L.
- Wareham N.J.
- Shaw J.E.
- Orchard T.J.
- Zhang P.
- et al.
The lancet commission on diabetes: using data to transform diabetes care and patient lives.Lancet.2020; 396: 2019-2082View in Article
-
- Gillies C.L.
- Abrams K.R.
- Lambert P.C.
- Cooper N.J.
- Sutton A.J.
- Hsu R.T.
- et al.
Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis.BMJ.2007; 334: 299View in Article
-
- Herman W.H.
- Ye W.
Precision prevention of diabetes.Diabetes Care.2023; 46: 1894-1896View in Article
-
- Rooney M.R.
- Fang M.
- Ogurtsova K.
- Ozkan B.
- Echouffo-Tcheugui J.B.
- Boyko E.J.
- et al.
Global prevalence of prediabetes.Diabetes Care.2023; 46: 1388-1394View in Article
-
- Zhang L.
- Zhang Y.
- Sa S.
- Wang X.
- Dong L.
- Li Q.
- et al.
Safety and effectiveness of metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial.Lancet Diabetes Endocrinol.2023; 11: 567-577View in Article
-
- Chan J.C.N.
- Paldánius P.M.
- Mathieu C.
- Stumvoll M.
- Matthews D.R.
- Del Prato S.
Early combination therapy delayed treatment escalation in newly diagnosed young-onset type 2 diabetes: a subanalysis of the VERIFY study.Diabetes Obes Metab.2021; 23: 245-251View in Article
-
- Holman R.R.
- Paul S.K.
- Bethel M.A.
- Matthews D.R.
- Neil H.A.W.
10-year follow-up of intensive glucose control in type 2 diabetes.N Engl J Med.2008; 359: 1577-1589View in Article
-
- Laiteerapong N.
- Ham S.A.
- Huang E.S.
- Karter A.J.
The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (the Diabetes & Aging study).Diabetes Care.2019; 42: 416-426View in Article
-
- Lind M.
- Imberg H.
- Coleman R.L.
- Nerman O.
- Holman R.R.
Historical hba1c values may explain the type 2 diabetes legacy effect: Ukpds 88.Diabetes Care.2021; 44: 2231-2237View in Article
-
- Matthews D.R.
- Paldánius P.M.
- Proot P.
- Chiang Y.
- Stumvoll M.
- Del Prato S.
Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial.Lancet.2019; 394: 1519-1529View in Article
-
- Qiao Q.
- Nakagami T.
- Tuomilehto J.
- Borch-Johnsen K.
- Balkau B.
- Iwamoto Y.
- et al.
Comparison of the fasting and the 2-h glucose criteria for diabetes in different Asian cohorts.Diabetologia.2000; 43: 1470-1475View in Article
-
- Bergman M.
- Buysschaert M.
- Schwarz P.E.H.
- Albright A.
- Narayan K.M.V.
- Yach D.
Diabetes prevention: global health policy and perspectives from the ground.Diabetes Manag (Lond).2012; 2: 309-321View in Article
-
- Cohen R.M.
- Haggerty S.
- Herman W.H.
HbA1c for the diagnosis of diabetes and prediabetes: is it time for a mid-course correction?.J Clin Endocrinol Metab.2010; 95: 5203-5206View in Article
-
- Herman W.H.
- Cohen R.M.
Racial and ethnic differences in the relationship between HbA1c and blood glucose: implications for the diagnosis of diabetes.J Clin Endocrinol Metab.2012; 97: 1067-1072View in Article
-
- Makaroff L.E.
The need for international consensus on prediabetes.Lancet Diabetes Endocrinol.2017; 5: 5-7View in Article
-
- James C.
- Bullard K.M.
- Rolka D.B.
- Geiss L.S.
- Williams D.E.
- Cowie C.C.
- et al.
Implications of alternative definitions of prediabetes for prevalence in U.S.Adults Diabetes Care.2011; 34: 387-391View in Article
-
- Mostafa S.A.
- Davies M.J.
- Srinivasan B.T.
- Carey M.E.
- Webb D.
- Khunti K.
Should glycated haemoglobin (HbA1c) be used to detect people with type 2 diabetes mellitus and impaired glucose regulation?.Postgrad Med J.2010; 86: 656-662View in Article
-
- Morris D.H.
- Khunti K.
- Achana F.
- Srinivasan B.
- Gray L.J.
- Davies M.J.
- et al.
Progression rates from HbA1c 6.0-6.4% and other prediabetes definitions to type 2 diabetes: a meta-analysis.Diabetologia.2013; 56: 1489-1493View in Article
-
- Anjana R.M.
- Rani C.S.S.
- Deepa M.
- Pradeepa R.
- Sudha V.
- Nair H.D.
- et al.
Incidence of diabetes and prediabetes and predictors of progression among asian indians: 10-year follow-up of the Chennai urban rural epidemiology study (CURES).Diabetes Care.2015; 38: 1441-1448View in Article
-
- Unwin N.
- Shaw J.
- Zimmet P.
- Alberti K.G.M.M.
Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention.Diabet Med.2002; 19: 708-723View in Article
-
- Bergman M.
- Buysschaert M.
- Ceriello A.
- Hussain A.
- Mohan V.
- Sesti G.
- et al.
Current diagnostic criteria identify risk for type 2 diabetes too late.Lancet Diabetes Endocrinol.2023; 11: 224-226View in Article
-
- Bergman M.
Inadequacies of absolute threshold levels for diagnosing prediabetes.Diabetes Metab Res Rev.2010; 26: 3-6View in Article
-
- Bergman M.
The early diabetes intervention program – is early actually late?.Diabetes Metab Res Rev.2014; 30: 654-658View in Article
-
- Bergman M.
- Dankner R.
- Roth J.
- Narayan K.M.V.
Are current diagnostic guidelines delaying early detection of dysglycemic states?.Time for new approaches Endocrine.2013; 44: 66-69View in Article
-
- Bergman M.
- Chetrit A.
- Roth J.
- Jagannathan R.
- Sevick M.
- Dankner R.
One-hour post-load plasma glucose level during the OGTT predicts dysglycemia: observations from the 24 year follow-up of the Israel study of glucose intolerance, obesity and hypertension.Diabetes Res Clin Pract.2016; 120: 221-228View in Article
-
- Bergman M.
- Dorcely B.
Remission of prediabetes via lifestyle intervention.Lancet Diabetes Endocrinol.2023; 11: 784-785View in Article
-
- Jagannathan R.
- Sevick M.A.
- Li H.
- Fink D.
- Dankner R.
- Chetrit A.
- et al.
Elevated 1-hour plasma glucose levels are associated with dysglycemia, impaired beta-cell function, and insulin sensitivity: a pilot study from a real world health care setting.Endocrine.2016; 52: 172-175View in Article
-
- Ohn J.H.
- Kwak S.H.
- Cho Y.M.
- Lim S.
- Jang H.C.
- Park K.S.
- et al.
10-year trajectory of β-cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study.Lancet Diabetes Endocrinol.2016; 4: 27-34View in Article
-
- Priya M.M.
- Amutha A.
- Pramodkumar T.A.
- Ranjani H.
- Jebarani S.
- Gokulakrishnan K.
- et al.
β-Cell function and insulin sensitivity in Normal glucose-tolerant subjects stratified by 1-hour plasma glucose values.Diabetes Technol Ther.2016; 18: 29-33View in Article
-
- Tirosh A.
- Shai I.
- Tekes-Manova D.
- Israeli E.
- Pereg D.
- Shochat T.
- et al.
Normal fasting plasma glucose levels and type 2 diabetes in young men.N Engl J Med.2005; 353: 1454-1462View in Article
-
- Ferrannini E.
- Manca M.L.
Identifying glucose thresholds for incident diabetes by physiological analysis: a mathematical solution.Am J Physiol Regul Integr Comp Physiol.2015; 308: R590-R596View in Article
- The DECODE Study Group. Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. The DECODE study group. European Diabetes Epidemiology Group. Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe. Lancet (Lond). 1999;354(9179):617-21.
- View in Article
-
- The DECODE Study Group
Is the current definition for diabetes relevant to mortality risk from all causes and cardiovascular and noncardiovascular diseases?.Diabetes Care.2003; 26: 688-696View in Article
-
- Sathish T.
- Khunti K.
- Narayan K.M.V.
- Mohan V.
- Davies M.J.
- Yates T.
- et al.
Effect of conventional lifestyle interventions on type 2 diabetes incidence by glucose-defined prediabetes phenotype: an individual participant data meta-analysis of randomized controlled trials.Diabetes Care.2023; 46: 1903-1907View in Article
-
- Weber M.B.
- Ranjani H.
- Staimez L.R.
- Anjana R.M.
- Ali M.K.
- Narayan K.M.V.
- et al.
The stepwise approach to diabetes prevention: results from the D-CLIP randomized controlled trial.Diabetes Care.2016; 39: 1760-1767View in Article
-
- Abdul-Ghani M.A.
- Abdul-Ghani T.
- Ali N.
- DeFronzo R.A.
One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes.Diabetes Care.2008; 31: 1650-1655View in Article
-
- Grundy S.M.
- Cleeman J.I.
- Daniels S.R.
- Donato K.A.
- Eckel R.H.
- Franklin B.A.
- et al.
Diagnosis and Management of the Metabolic Syndrome.Circulation.2005; 112: 2735-2752View in Article
-
- Alyass A.
- Almgren P.
- Akerlund M.
- Dushoff J.
- Isomaa B.
- Nilsson P.
- et al.
Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts.Diabetologia.2015; 58: 87-97View in Article
-
- Abdul-Ghani M.A.
- Stern M.P.
- Lyssenko V.
- Tuomi T.
- Groop L.
- DeFronzo R.A.
Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with Normal 2-h plasma glucose.Diabetes Care.2010; 33: 557-561View in Article
-
- Priya M.
- Anjana R.M.
- Chiwanga F.S.
- Gokulakrishnan K.
- Deepa M.
- Mohan V.
1-hour venous plasma glucose and incident prediabetes and diabetes in asian indians.Diabetes Technol Ther.2013; 15: 497-502View in Article
-
- Fiorentino T.V.
- Marini M.A.
- Andreozzi F.
- Arturi F.
- Succurro E.
- Perticone M.
- et al.
One-hour postload hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose.J Clin Endocrinol Metab.2015; 100: 3744-3751View in Article
-
- Oka R.
- Aizawa T.
- Miyamoto S.
- Yoneda T.
- Yamagishi M.
One-hour plasma glucose as a predictor of the development of type 2 diabetes in Japanese adults.Diabet Med.2016; 33: 1399-1405View in Article
-
- Oh T.J.
- Lim S.
- Kim K.M.
- Moon J.H.
- Choi S.H.
- Cho Y.M.
- et al.
One-hour postload plasma glucose concentration in people with normal glucose homeostasis predicts future diabetes mellitus: a 12-year community-based cohort study.Clin Endocrinol.2017; 86: 513-519View in Article
-
- Paddock E.
- Hohenadel M.G.
- Piaggi P.
- Vijayakumar P.
- Hanson R.L.
- Knowler W.C.
- et al.
One-hour and two-hour postload plasma glucose concentrations are comparable predictors of type 2 diabetes mellitus in southwestern native americans.Diabetologia.2017; 60: 1704-1711View in Article
-
- Pareek M.
- Bhatt D.L.
- Nielsen M.L.
- Jagannathan R.
- Eriksson K.F.
- Nilsson P.M.
- et al.
Enhanced predictive capability of a 1-hour Oral glucose tolerance test: a prospective population-based cohort study.Diabetes Care.2018; 41: 171-177View in Article
-
- Sai Prasanna N.
- Amutha A.
- Pramodkumar T.A.
- Anjana R.M.
- Venkatesan U.
- Priya M.
- et al.
The 1h post glucose value best predicts future dysglycemia among normal glucose tolerance subjects.J Diabetes Complications.2017; 31: 1592-1596View in Article
-
- Strandberg T.E.
- Pienimäki T.
- Strandberg A.Y.
- Salomaa V.V.
- Pitkälä K.H.
- Tilvis R.S.
- et al.
One-hour glucose, mortality, and risk of diabetes: a 44-year prospective study in men.Arch Intern Med.2011; 171: 941-943View in Article
-
- Thewjitcharoen Y.
- Elizabeth Jones A.
- Butadej S.
- Nakasatien S.
- Chotwanvirat P.
- Wanothayaroj E.
- et al.
Elevated 1-h post-load plasma glucose levels in thai people with normal glucose tolerance associated with high diabetes and cardiovascular risk.Diabet Med.2020; 37: 705-706View in Article
-
- Kumpatla S.
- Parveen R.
- Stanson S.
- Viswanathan V.
Elevated one hour with normal fasting and 2 h plasma glucose helps to identify those at risk for development of Type2 Diabetes-11 years observational study from South India.Diabetes Metab Syndr.2019; 13: 2733-2737View in Article
-
- Manco M.
- Mari A.
- Petrie J.
- Mingrone G.
- Balkau B.
One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort.Diabetologia.2019; 62: 544-548View in Article
-
- Briker S.M.
- Hormenu T.
- Dubose C.W.
- Mabundo L.S.
- Chung S.T.
- Ha J.
- et al.
Metabolic characteristics of Africans with normal glucose tolerance and elevated 1-hour glucose: insight from the Africans in America study.BMJ Open Diabetes Res Care.2020; 8e000837View in Article
-
- Saunajoki A.E.
- Auvinen J.P.
- Bloigu A.H.
- Timonen M.J.
- Keinänen-Kiukaanniemi S.M.
Evaluating the 1-h post-load glucose level to predict future type 2 diabetes.Diabetes Res Clin Pract.2020; 160108009View in Article
-
- Rong L.
- Luo N.
- Gong Y.
- Tian H.
- Sun B.
- Li C.
One-hour plasma glucose concentration can identify elderly Chinese male subjects at high risk for future type 2 diabetes mellitus: a 20-year retrospective and prospective study.Diabetes Res Clin Pract.2021; 173108683View in Article
-
- Peddinti G.
- Bergman M.
- Tuomi T.
- Groop L.
1-hour post-OGTT glucose improves the early prediction of type 2 diabetes by clinical and metabolic markers.J Clin Endocrinol Metab.2019; 104: 1131-1140View in Article
-
- Abdul-Ghani M.A.
- Abdul-Ghani T.
- Stern M.P.
- Karavic J.
- Tuomi T.
- Bo I.
- et al.
Two-step approach for the prediction of future type 2 diabetes risk.Diabetes Care.2011; 34: 2108-2112View in Article
-
- Kasturi K.
- Onuzuruike A.U.
- Kunnam S.
- Shomaker L.B.
- Yanovski J.A.
- Chung S.T.
Two- vs one-hour glucose tolerance testing: predicting prediabetes in adolescent girls with obesity.Pediatr Diabetes.2019; 20: 154-159View in Article
- National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979;28(12):1039-57.
- View in Article
-
- Rushforth N.B.
- Bennett P.H.
- Steinberg A.G.
- Miller M.
Comparison of the value of the two- and one-hour glucose levels of the oral GTT in the diagnosis of diabetes in Pima Indians.Diabetes.1975; 24: 538-546View in Article
-
- Bartoli E.
- Fra G.P.
- Carnevale Schianca G.P.
The oral glucose tolerance test (OGTT) revisited.Eur J Intern Med.2011; 22: 8-12View in Article
-
- Paddock E.
- Looker H.C.
- Piaggi P.
- Knowler W.C.
- Krakoff J.
- Chang D.C.
One-hour plasma glucose compared with two-hour plasma glucose in relation to diabetic retinopathy in american indians.Diabetes Care.2018; 41: 1212-1217View in Article
-
- Saunajoki A.
- Auvinen J.
- Saarela V.
- Uusitalo J.J.
- Leiviska I.
- Keinanen-Kiukaanniemi S.
- et al.
Association of glucose metabolism and retinopathy signs in non-diabetic individuals in midlife-the northern Finland birth cohort 1966 study.PLoS One.2020; 15e0240983View in Article
-
- Jagannathan R.
- Sevick M.A.
- Fink D.
- Dankner R.
- Chetrit A.
- Roth J.
- et al.
The 1-hour post-load glucose level is more effective than HbA1c for screening dysglycemia.Acta Diabetol.2016; 53: 543-550View in Article
-
- Abdul-Ghani M.A.
- Abdul-Ghani T.
- Müller G.
- Bergmann A.
- Fischer S.
- Bornstein S.
- et al.
Role of glycated haemoglobin in the prediction of future risk of T2DM.J Clin Endocrinol Metab.2011; 96: 2596-2600View in Article
-
- Abdul-Ghani M.A.
- Williams K.
- DeFronzo R.A.
- Stern M.
What is the best predictor of future type 2 diabetes?.Diabetes Care.2007; 30: 1544-1548View in Article
-
- Manco M.
- Panunzi S.
- Macfarlane D.P.
- Golay A.
- Melander O.
- Konrad T.
- et al.
One-hour plasma glucose identifies insulin resistance and β-cell dysfunction in individuals with Normal glucose tolerance: cross-sectional data from the relationship between insulin sensitivity and cardiovascular risk (RISC) study.Diabetes Care.2010; 33: 2090-2097View in Article
-
- Gyberg V.
- De Bacquer D.
- Kotseva K.
- De Backer G.
- Schnell O.
- Tuomilehto J.
- et al.
Time-saving screening for diabetes in patients with coronary artery disease: a report from EUROASPIRE IV.BMJ Open.2016; 6: e013835View in Article
- The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997;20(7):1183-97.
- View in Article
-
- Sayegh H.A.
- Jarrett R.J.
Oral glucose-tolerance tests and the diagnosis of diabetes: results of a prospective study based on the Whitehall survey.Lancet.1979; 2: 431-433View in Article
-
- McCance D.R.
- Hanson R.L.
- Charles M.A.
- Jacobsson L.T.H.
- Pettitt D.D.
- Bennett P.H.
- et al.
Comparison of tests for glycated haemoglobin and fasting and two hour plasma glucose concentrations as diagnostic methods for diabetes.BMJ.1994; 308: 1323-1328View in Article
-
- Pettitt D.J.
- Knowler W.C.
- Lisse J.R.
- Bennett P.H.
Development of retinopathy and proteinuria in relation to plasma-glucose concentrations in Pima Indians.Lancet.1980; 2: 1050-1052View in Article
-
- Engelgau M.M.
- Thompson T.J.
- Herman W.H.
- Boyle J.P.
- Aubert R.E.
- Kenny S.J.
- et al.
Comparison of fasting and 2-hour glucose and HbA1c levels for diagnosing diabetes. Diagnostic criteria and performance revisited.Diabetes Care.1997; 20: 785-791View in Article
-
- Succurro E.
- Arturi F.
- Lugarà M.
- Grembiale A.
- Fiorentino T.V.
- Caruso V.
- et al.
One-hour postload plasma glucose levels are associated with kidney dysfunction.Clin J Am Soc Nephrol.2010; 5: 1922-1927View in Article
-
- Cassano V.
- Pelaia C.
- Armentaro G.
- Miceli S.
- Tallarico V.
- Perini D.D.
- et al.
New potential biomarkers for early chronic kidney disease diagnosis in patients with different glucose tolerance status.Front Endocrinol.2023; 14: 1206336View in Article
-
- Saunajoki A.
- Auvinen J.
- Bloigu A.
- Saramies J.
- Tuomilehto J.
- Uusitalo H.
- et al.
Elevated one-hour post-load glucose is independently associated with albuminuria: a cross-sectional population study.J Clin Med.2022; 11: 4124View in Article
-
- Lind M.
- Tuomilehto J.
- Uusitupa M.
- Nerman O.
- Eriksson J.
- LlanneParikka P.
- et al.
The association between Hba1c, fasting glucose, 1-hour glucose and 2-hour glucose during an oral glucose tolerance test and cardiovascular disease in individuals with elevated risk for diabetes.PLoS One.2014; 9: e109506View in Article
-
- Abdul-Ghani M.A.
- Lyssenko V.
- Tuomi T.
- DeFronzo R.A.
- Groop L.
Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the botnia study.Diabetes Care.2009; 32: 281-286View in Article
-
- Nakagomi A.
- Sunami Y.
- Okada S.
- Ohno Y.
- Shoji T.
- Fujisawa T.
- et al.
Association between 1-h post-load plasma glucose levels and arterial stiffness in normotensive subjects with normal glucose tolerance.Diab Vasc Dis Res.2018; 15: 39-45View in Article
-
- Fiorentino T.V.
- Sesti F.
- Andreozzi F.
- Pedace E.
- Succurro E.
- Sciacqua A.
- et al.
Frequency of 1-h post-load glucose ≥155 mg/dl among individuals with different glucose tolerance conditions.Nutr Metab Cardiovasc Dis.2016; 26: 439-441View in Article
-
- Bardini G.
- Dicembrini I.
- Cresci B.
- Rotella C.M.
Inflammation markers and metabolic characteristics of subjects with 1-h plasma glucose levels.Diabetes Care.2010; 33: 411-413View in Article
-
- Bianchi C.
- Miccoli R.
- Trombetta M.
- Giorgino F.
- Frontoni S.
- Faloia E.
- et al.
Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired β-cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study.J Clin Endocrinol Metab.2013; 98: 2100-2105View in Article
-
- Kim J.Y.
- Goran M.I.
- Toledo-Corral C.M.
- Weigensberg M.J.
- Choi M.
- Shaibi G.Q.
One-hour glucose during an Oral glucose challenge prospectively predicts β-cell deterioration and prediabetes in obese hispanic youth.Diabetes Care.2013; 36: 1681-1686View in Article
-
- Fintini D.
- Cappa M.
- Brufani C.
- Bernardini S.
- Barbetti F.
Prevalence of elevated 1-h plasma glucose and its associations in obese youth.Diabetes Res Clin Pract.2016; 116: 202-204View in Article
-
- Ha J.
- Chung S.T.
- Bogardus C.
- Jagannathan R.
- Bergman M.
- Sherman A.S.
One-hour glucose is an earlier marker of dysglycemia than two-hour glucose.Diabetes Res Clin Pract.2023; 203110839View in Article
-
- Ahuja V.
- Aronen P.
- Pramodkumar T.A.
- Looker H.
- Chetrit A.
- Bloigu A.H.
- et al.
Accuracy of 1-hour plasma glucose during the Oral glucose tolerance test in diagnosis of type 2 diabetes in adults: a meta-analysis.Diabetes Care.2021; 44: 1062-1069View in Article
-
- Tabák A.G.
- Jokela M.
- Akbaraly T.N.
- Brunner E.J.
- Kivimäki M.
- Witte D.R.
Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study.Lancet.2009; 373: 2215-2221View in Article
-
- Ferrannini E.
- Gastaldelli A.
- Miyazaki Y.
- Matsuda M.
- Mari A.
- DeFronzo R.A.
β-Cell function in subjects spanning the range from Normal glucose tolerance to overt diabetes: a new analysis.J Clin Endocrinol Metab.2005; 90: 493-500View in Article
-
- Chow E.Y.K.
- Chan J.C.N.
Insulin resistance versus β-cell dysfunction in type 2 diabetes: where public and personalised health meet.Lancet Diabetes Endocrinol.2020; 8: 92-93View in Article
-
- Yabe D.
- Seino Y.
Type 2 diabetes via β-cell dysfunction in east Asian people.Lancet Diabetes Endocrinol.2016; 4: 2-3View in Article
-
- Staimez L.R.
- Weber M.B.
- Ranjani H.
- Ali M.K.
- Echouffo-Tcheugui J.B.
- Phillips L.S.
- et al.
Evidence of reduced β-cell function in Asian Indians with mild dysglycemia.Diabetes Care.2013; 36: 2772-2778View in Article
-
- Tura A.
- Grespan E.
- Göobl C.S.
- Koivula R.W.
- Franks P.W.
- Pearson E.R.
- et al.
Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated haemoglobin, and 1-hour OGTT: an IMI DIRECT study.Diabetes.2021; 70: 2092-2106View in Article
-
- Sato M.
- Tamura Y.
- Someya Y.
- Takeno K.
- Kaga H.
- Kadowaki S.
- et al.
Characteristics associated with elevated 1-h plasma glucose levels during a 75-g oral glucose tolerance test in non-obese Japanese men.J Diabetes Investig.2020; 11: 1520-1523View in Article
-
- Jalleh R.J.
- Marathe C.S.
- Trahair L.G.
- Jones K.L.
- Horowitz M.
A biphasic glucose response during an oral glucose tolerance test is associated with greater plasma insulin and GLP-1 responses and a reduction in 1-hour glucose but does not relate to the rate of gastric emptying in healthy, older adults.Nutrients.2023; 15: 3889View in Article
-
- Mann B.K.
- Bhandohal J.S.
- Hong J.
An overall glance of evidence supportive of one-hour and two-hour postload plasma glucose levels as predictors of long-term cardiovascular events.Int J Endocrinol.2019; 2019: 6048954View in Article
-
- Ceriello A.
Targeting one-hour postmeal glucose: is it time for a paradigm switch in diabetes management?.Diabetes Technol Ther.2017; 19: 493-497View in Article
-
- Guerreiro V.
- Maia I.
- Neves J.S.
- Salazar D.
- Ferreira M.J.
- Mendonça F.
- et al.
Oral glucose tolerance testing at 1 h and 2 h: relationship with glucose and cardiometabolic parameters and agreement for pre-diabetes diagnosis in patients with morbid obesity.Diabetol Metab Syndr.2022; 14: 91View in Article
-
- Marini M.A.
- Succurro E.
- Frontoni S.
- Mastroianni S.
- Arturi F.
- Sciacqua A.
- et al.
Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-hour postload plasma glucose levels.Diabetes Care.2012; 35: 868-872View in Article
-
- Succurro E.
- Arturi F.
- Grembiale A.
- Iorio F.
- Fiorentino T.V.
- Andreozzi F.
- et al.
One-hour post-load plasma glucose levels are associated with elevated liver enzymes.Nutr Metab Cardiovasc Dis.2011; 21: 713-718View in Article
-
- Sesti G.
- Hribal M.L.
- Fiorentino T.V.
- Sciacqua A.
- Perticone F.
Elevated 1 h postload plasma glucose levels identify adults with normal glucose tolerance but increased risk of non-alcoholic fatty liver disease.BMJ Open Diabetes Res Care.2014; 2e000016View in Article
-
- Haverals L.
- Van Dessel K.
- Verrijken A.
- Dirinck E.
- Peiffer F.
- Verhaegen A.
- et al.
Cardiometabolic importance of 1-h plasma glucose in obese subjects.Nutr Diabetes.2019; 9: 16View in Article
-
- Pramodkumar T.
- Priya M.
- Jebarani S.
- Anjana R.
- Mohan V.
- Pradeepa R.
Metabolic profile of normal glucose-tolerant subjects with elevated 1-h plasma glucose values.Indian J Endocrinol Metab.2016; 20: 612-618View in Article
-
- Park S.K.
- Ryoo J.H.
- Oh C.M.
- Choi J.M.
- Jung J.Y.
1-hour and 2-hour postload glucose level on oral glucose tolerance test and the risk of incident metabolic syndrome.J Clin Endocrinol Metab.2019; 104: 539-549View in Article
-
- Andreozzi F.
- Mannino G.C.
- Perticone M.
- Perticone F.
- Sesti G.
Elevated 1-h post-load plasma glucose levels in subjects with normal glucose tolerance are associated with a pro-atherogenic lipid profile.Atherosclerosis.2017; 256: 15-20View in Article
-
- Abbasi F.
- Tern P.J.
- Reaven G.M.
Plasma glucose concentration 60 min post oral glucose load and risk of type 2 diabetes and cardiovascular disease: pathophysiological implications.Diab Vasc Dis Res.2019; 16: 337-343View in Article
-
- Perticone F.
- Sciacqua A.
- Perticone M.
- Arturi F.
- Scarpino P.E.
- Quero M.
- et al.
Serum uric acid and 1-h postload glucose in essential hypertension.Diabetes Care.2012; 35: 153-157View in Article
-
- Marini M.A.
- Fiorentino T.V.
- Andreozzi F.
- Mannino G.C.
- Perticone M.
- Sciacqua A.
- et al.
Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity.Acta Diabetol.2017; 54: 775-784View in Article
-
- Sciacqua A.
- Perticone M.
- Grillo N.
- Falbo T.
- Bencardino G.
- Angotti E.
- et al.
Vitamin D and 1-hour post-load plasma glucose in hypertensive patients.Cardiovasc Diabetol.2014; 13: 48View in Article
-
- Sesti G.
- Fiorentino T.V.
- Succurro E.
- Perticone M.
- Arturi F.
- Sciacqua A.
- et al.
Elevated 1-h post-load plasma glucose levels in subjects with normal glucose tolerance are associated with unfavorable inflammatory profile.Acta Diabetol.2014; 51: 927-932View in Article
-
- Perticone M.
- Maio R.
- Gigliotti S.
- Arturi F.
- Succurro E.
- Sciacqua A.
- et al.
Immuno-mediated inflammation in hypertensive patients with 1-h post-load hyperglycemia.Int J Mol Sci.2022; 23: 10891View in Article
-
- Cassano V.
- Miceli S.
- Armentaro G.
- Mannino G.C.
- Fiorentino V.T.
- Perticone M.
- et al.
Oxidative stress and left ventricular performance in patients with different glycometabolic phenotypes.Nutrients.2022; 14: 1299View in Article
-
- Perticone F.
- Sciacqua A.
- Tassone E.J.
- Miceli S.
- Maio R.
- Addesi D.
- et al.
One-hour post-load plasma glucose and IGF-1 in hypertensive patients.Eur J Clin Invest.2012; 42: 1325-1331View in Article
-
- La Sala L.
- Tagliabue E.
- de Candia P.
- Prattichizzo F.
- Ceriello A.
One-hour plasma glucose combined with skin autofluorescence identifies subjects with pre-diabetes: the DIAPASON study.BMJ Open Diabetes Res Care.2020; 8View in Article
-
- Di Pino A.
- Urbano F.
- Scicali R.
- Di Mauro S.
- Filippello A.
- Scamporrino A.
- et al.
1 h postload glycemia is associated with low endogenous secretory receptor for advanced glycation end product levels and early markers of cardiovascular disease.Cells.2019; 8View in Article
-
- Succurro E.
- Marini M.A.
- Arturi F.
- Grembiale A.
- Lugarà M.
- Andreozzi F.
- et al.
Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis.Atherosclerosis.2009; 207: 245-249View in Article
-
- Tanaka K.
- Kanazawa I.
- Yamaguchi T.
- Sugimoto T.
One-hour post-load hyperglycemia by 75g oral glucose tolerance test as a novel risk factor of atherosclerosis.Endocr J.2014; 61: 329-334View in Article
-
- Fiorentino T.V.
- Sesti F.
- Andreozzi F.
- Pedace E.
- Sciacqua A.
- Hribal M.L.
- et al.
One-hour post-load hyperglycemia combined with HbA1c identifies pre-diabetic individuals with a higher cardio-metabolic risk burden.Atherosclerosis.2016; 253: 61-69View in Article
-
- Sciacqua A.
- Maio R.
- Miceli S.
- Pascale A.
- Carullo G.
- Grillo N.
- et al.
Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension.PLoS One.2012; 7e44470View in Article
-
- Nakagomi A.
- Sunami Y.
- Okada S.
- Fujisawa T.
- Kobayashi Y.
Synergistic effects of 1 h post-load plasma glucose and smoking on arterial stiffness in apparently healthy men: a cross-sectional study.J Atheroscler Thromb.2019; 26: 505-512View in Article
-
- Sciacqua A.
- Miceli S.
- Carullo G.
- Greco L.
- Succurro E.
- Arturi F.
- et al.
One-hour postload plasma glucose levels and left ventricular mass in hypertensive patients.Diabetes Care.2011; 34: 1406-1411View in Article
-
- Sciacqua A.
- Miceli S.
- Greco L.
- Arturi F.
- Naccarato P.
- Mazzaferro D.
- et al.
One-hour postload plasma glucose levels and diastolic function in hypertensive patients.Diabetes Care.2011; 34: 2291-2296View in Article
-
- Sciacqua A.
- Perticone M.
- Miceli S.
- Pinto A.
- Cassano V.
- Succurro E.
- et al.
Elevated 1-h post-load plasma glucose is associated with right ventricular morphofunctional parameters in hypertensive patients.Endocrine.2019; 64: 525-535View in Article
-
- Miceli S.
- Cassano V.
- Clausi E.
- Armentaro G.
- Tallarico V.
- Dallimonti Perini D.
- et al.
One-hour post-load glucose and subclinical left atrial myocardial dysfunction in hypertensive patients.Eur J Clin Invest.2023; 53e14009View in Article
-
- Succurro E.
- Pedace E.
- Andreozzi F.
- Papa A.
- Vizza P.
- Fiorentino T.V.
- et al.
Reduction in global myocardial glucose metabolism in subjects with 1-hour postload hyperglycemia and impaired glucose tolerance.Diabetes Care.2020; 43: 669-676View in Article
-
- Fiorentino T.V.
- Miceli S.
- Succurro E.
- Sciacqua A.
- Andreozzi F.
- Sesti G.
Depressed myocardial mechano-energetic efficiency in subjects with dysglycemia.Diabetes Res Clin Pract.2021; 177108883View in Article
-
- Perticone M.
- Di Lorenzo C.
- Arabia G.
- Arturi F.
- Caroleo B.
- Tassone B.
- et al.
One hour-post-load plasma glucose ≥155 mg/dl in healthy glucose normotolerant subjects is associated with subcortical brain MRI alterations and impaired cognition: a pilot study.Front Aging Neurosci.2021; 13608736View in Article
-
- Fiorentino T.V.
- De Vito F.
- Suraci E.
- Marasco R.
- Catalano F.
- Andreozzi F.
- et al.
Augmented duodenal levels of sodium/glucose co-transporter 1 are associated with higher risk of nonalcoholic fatty liver disease and noninvasive index of liver fibrosis.Diabetes Res Clin Pract.2022; 185109789View in Article
-
- Fiorentino T.V.
- Andreozzi F.
- Mannino G.C.
- Pedace E.
- Perticone M.
- Sciacqua A.
- et al.
One-hour postload hyperglycemia confers higher risk of hepatic steatosis to HbA1c-defined IH subjects.J Clin Endocrinol Metab.2016; 101: 4030-4038View in Article
-
- Jagannathan R.
- Fiorentino T.V.
- Marini M.A.
- Sesti G.
- Bergman M.
One-hour post-load glucose is associated with severity of hepatic fibrosis risk.Diabetes Res Clin Pract.2022; 189109977View in Article
-
- Brodsky J.
- Dougherty S.
- Makani R.
- Rubenstein R.C.
- Kelly A.
Elevation of 1-hour plasma glucose during oral glucose tolerance testing is associated with worse pulmonary function in cystic fibrosis.Diabetes Care.2011; 34: 292-295View in Article
-
- Lorenz A.N.
- Pyle L.
- Ha J.
- Sherman A.
- Cree-Green M.
- Sagel S.D.
- et al.
Predictive value of 1-hour glucose elevations during oral glucose tolerance testing for cystic fibrosis-related diabetes.Pediatr Diabetes.2023; 20234395556View in Article
-
- Nyirjesy S.C.
- Sheikh S.
- Hadjiliadis D.
- De Leon D.D.
- Peleckis A.J.
- Eiel J.N.
- et al.
β-Cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1-hour oral glucose tolerance test glucose ≥155 mg/dL.Pediatr Diabetes.2018; 19: 1173-1182View in Article
-
- Schmid K.
- Fink K.
- Holl R.W.
- Hebestreit H.
- Ballmann M.
Predictors for future cystic fibrosis-related diabetes by oral glucose tolerance test.J Cyst Fibros.2014; 13: 80-85View in Article
-
- Sheikh S.
- Putt M.E.
- Forde K.A.
- Rubenstein R.C.
- Kelly A.
Elevation of one hour plasma glucose during oral glucose tolerance testing.Pediatr Pulmonol.2015; 50: 963-969View in Article
-
- Tommerdahl K.L.
- Brinton J.T.
- Vigers T.
- Cree-Green M.
- Zeitler P.S.
- Nadeau K.J.
- et al.
Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index.J Cyst Fibros.2021; 20: 339-345View in Article
-
- Orencia A.J.
- Daviglus M.L.
- Dyer A.R.
- Walsh M.
- Greenland P.
- Stamler J.
One-hour postload plasma glucose and risks of fatal coronary heart disease and stroke among nondiabetic men and women: the Chicago heart association detection project in industry (CHA) study.J Clin Epidemiol.1997; 50: 1369-1376View in Article
-
- Donahue R.P.
- Abbott R.D.
- Reed D.M.
- Yano K.
Postchallenge glucose concentration and coronary heart disease in men of Japanese ancestry.Honolulu Heart Program Diabetes.1987; 36: 689-692View in Article
-
- Cao L.
- Wang P.
- Luan H.
- Chen H.
- Luo C.
- Zhu D.
- et al.
Elevated 1-h postload plasma glucose levels identify coronary heart disease patients with greater severity of coronary artery lesions and higher risk of 1-year re-admission.Diab Vasc Dis Res.2020; 171479164119896978View in Article
-
- Fiorentino T.V.
- Succurro E.
- Andreozzi F.
- Sciacqua A.
- Perticone F.
- Sesti G.
One-hour post-load hyperglycemia combined with HbA1c identifies individuals with higher risk of cardiovascular diseases: cross-sectional data from the CATAMERI study.Diabetes Metab Res Rev.2019; 35e3096View in Article
-
- Saunajoki A.
- Auvinen J.
- Bloigu A.
- Ukkola O.
- Keinänen-Kiukaanniemi S.
- Timonen M.
One-hour post-load glucose improves the prediction of cardiovascular events in the OPERA study.Ann Med.2021; 53: 478-484View in Article
-
- Rong L.
- Cheng X.
- Yang Z.
- Gong Y.
- Li C.
- Yan S.
- et al.
One-hour plasma glucose as a long-term predictor of cardiovascular events and all-cause mortality in a chinese older male population without diabetes: a 20-year retrospective and prospective study.Front Cardiovasc Med.2022; 9947292View in Article
-
- Zywicki V.
- Capozza P.
- Caravelli P.
- Del Prato S.
- De Caterina R.
Glucose tolerance and markers of myocardial injury after an acute coronary syndrome: predictive role of the 1-h plus 2-h plasma glucose at the oral glucose tolerance test.Cardiovasc Diabetol.2022; 21: 152View in Article
-
- Meisinger C.
- Wölke G.
- Brasche S.
- Strube G.
- Heinrich J.
Postload plasma glucose and 30-year mortality among nondiabetic middle-aged men from the general population: the ERFORT study.Ann Epidemiol.2006; 16: 534-539View in Article
-
- Bergman M.
- Chetrit A.
- Roth J.
- Dankner R.
One-hour post-load plasma glucose level during the OGTT predicts mortality: observations from the Israel study of glucose intolerance.Obesity and Hypertension Diabet Med.2016; 33: 1060-1068View in Article
-
- Nielsen M.L.
- Pareek M.
- Leósdóttir M.
- Eriksson K.F.
- Nilsson P.M.
- Olsen M.H.
One-hour glucose value as a long-term predictor of cardiovascular morbidity and mortality: the Malmö preventive project.Eur J Endocrinol.2018; 178: 225-236View in Article
-
- Li N.
- Fan Y.
- Zhou J.P.
- Maimba O.D.
- Zhang L.
- Li Q.Y.
Obstructive sleep apnea exacerbates glucose dysmetabolism and pancreatic β-cell dysfunction in overweight and obese nondiabetic young adults.Diabetes Metab Syndr Obes.2020; 13: 2465-2476View in Article
-
- Pamidi S.
- Benedetti A.
- Tasali E.
One hour post-load glucose levels among patients with obstructive sleep apnea and normal glucose tolerance.J Diabetes Complications.2023; 37108551View in Article
-
- Umano G.R.
- Galderisi A.
- Aiello F.
- Martino M.
- Camponesco O.
- Di Sessa A.
- et al.
Obstructive sleep apnea (OSA) is associated with the impairment of beta-cell response to glucose in children and adolescents with obesity.Int J Obes (Lond).2023; 47: 257-262View in Article
-
- Younossi Z.M.
- Koenig A.B.
- Abdelatif D.
- Fazel Y.
- Henry L.
- Wymer M.
Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes.Hepatology.2016; 64: 73-84View in Article
-
- Adams L.A.
- Anstee Q.M.
- Tilg H.
- Targher G.
Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases.Gut.2017; 66: 1138-1153View in Article
-
- Andreozzi F.
- Mancuso E.
- Mazza E.
- Mannino G.C.
- Fiorentino T.V.
- Arturi F.
- et al.
One-hour post-load glucose levels are associated with hepatic steatosis assessed by transient elastography.Diabetes Obes Metab.2023; 26: 682-689View in Article
-
- Lebeaupin C.
- Vallée D.
- Hazari Y.
- Hetz C.
- Chevet E.
- Bailly-Maitre B.
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease.J Hepatol.2018; 69: 927-947View in Article
-
- Jesrani G.
- Gupta M.
- Kaur J.
- Kaur N.
- Lehl S.
- Singh R.
One-hour postload plasma glucose in obese indian adults with nonalcoholic fatty liver disease: an observational study from North India.Indian J Endocrinol Metab.2021; 25: 450-455View in Article
-
- Knowler W.C.
- Barrett-Connor E.
- Fowler S.E.
- Hamman R.F.
- Lachin J.M.
- Walker E.A.
- et al.
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.N Engl J Med.2002; 346: 393-403View in Article
- Diabetes Prevention Program Research Group. Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study. Lancet Diabetes Endocrinol. 2015;3(11):866-75.
- View in Article
-
- Golovaty I.
- Ritchie N.D.
- Tuomilehto J.
- Mohan V.
- Ali M.K.
- Gregg E.W.
- et al.
Two decades of diabetes prevention efforts: a call to innovate and revitalize our approach to lifestyle change.Diabetes Res Clin Pract.2023; 198: 110195View in Article
-
- Molitch M.E.
- Fujimoto W.
- Hamman R.F.
- Knowler W.C.
The diabetes prevention program and its global implications.J Am Soc Nephrol.2003; 14: S103-S107View in Article
-
- Tuomilehto J.
- Uusitupa M.
- Gregg E.W.
- Lindström J.
Type 2 diabetes prevention programs—from proof-of-concept trials to national intervention and beyond.J Clin Med.2023; 12: 1876View in Article
-
- Armato J.P.
- DeFronzo R.A.
- Abdul-Ghani M.
- Ruby R.J.
Successful treatment of prediabetes in clinical practice using physiological assessment (STOP DIABETES).Lancet Diabetes Endocrinol.2018; 6: 781-789View in Article
-
- Andellini M.
- Manco M.
- Esposito M.T.
- Tozzi A.E.
- Bergman M.
- Ritrovato M.
A simulation model estimates lifetime health and economic outcomes of screening prediabetes using the 1-h plasma glucose.Acta Diabetol.2023; 60: 9-17View in Article
-
- Perreault L.
- Kahn S.E.
- Christophi C.A.
- Knowler W.C.
- Hamman R.F.
Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program.Diabetes Care.2009; 32: 1583-1588View in Article
- American Diabetes Association Professional Practice Committee. 14. Children and adolescents: standards of medical care in diabetes—2022. Diabetes Care. 2022;45(Supplement_1):S208-S31.
- View in Article
-
- Brufani C.
- Tura A.
- Bedogni G.
- Luciano R.
- Sbrignadello S.
- Fintini D.
- et al.
Inside out the ragbag of glucose intolerance in obese adolescents.Horm Res Paediatr.2017; 87: 287-294View in Article
-
- Galderisi A.
- Giannini C.
- Weiss R.
- Kim G.
- Shabanova V.
- Santoro N.
- et al.
Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis.Lancet Child Adolesc Health.2018; 2: 726-735View in Article
-
- Savoye M.
- Caprio S.
- Dziura J.
- Camp A.
- Germain G.
- Summers C.
- et al.
Reversal of early abnormalities in glucose metabolism in obese youth: Results of an intensive lifestyle randomized controlled trial.Diabetes Care.2014; 37: 317-324View in Article
-
- Pedicelli S.
- Fintini D.
- Ravà L.
- Inzaghi E.
- Deodati A.
- Spreghini M.R.
- et al.
Prevalence of prediabetes in children and adolescents by class of obesity.Pediatr Obes.2022; 17e12900View in Article
-
- Ravà L.
- Fintini D.
- Mariani M.
- Deodati A.
- Inzaghi E.
- Pedicelli S.
- et al.
High 1-h glucose in youths with obesity as marker of prediabetes and cardiovascular risk.J Endocrinol Invest.2023; 46: 2555-2562View in Article
-
- Manco M.
- Miraglia Del Giudice E.
- Spreghini M.R.
- Cappa M.
- Perrone L.
- Brufani C.
- et al.
1-hour plasma glucose in obese youth.Acta Diabetol.2012; 49: 435-443View in Article
-
- Mengen E.
- Uçaktürk S.A.
Evaluation of the relationship between the one-hour plasma glucose concentration and beta-cell functions and cardiometabolic parameters during oral glucose tolerance test in obese children and adolescents.J Pediatr Endrocrinol Metab.2020; 33: 767-775View in Article
-
- Tfayli H.
- Jung Lee S.
- Bacha F.
- Arslanian S.
One-hour plasma glucose concentration during the OGTT: what does it tell about β-cell function relative to insulin sensitivity in overweight/obese children?.Pediatr Diabetes.2011; 12: 572-579View in Article
-
- Tricò D.
- Galderisi A.
- Mari A.
- Santoro N.
- Caprio S.
One-hour post-load plasma glucose predicts progression to prediabetes in a multi-ethnic cohort of obese youths.Diabetes Obes Metab.2019; 21: 1191-1198View in Article
-
- Brar P.C.
- Mehta S.
- Brar A.
- Pierce K.A.
- Albano A.
- Bergman M.
Value of 1-hour plasma glucose during an Oral glucose tolerance test in a multiethnic cohort of obese children and adolescents.Clin Med Insights Endocrinol Diabetes.2023; 1611795514231177206View in Article
-
- The DECODE Study Group
Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts.Diabetes Care.2003; 26: 61-69View in Article
-
- The DECODA Study Group
Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts.Diabetes Care.2003; 26: 1770-1780View in Article
-
- Wahl P.W.
- Savage P.J.
- Psaty B.M.
- Orchard T.J.
- Robbins J.A.
- Tracy R.P.
Diabetes in older adults: comparison of 1997 American Diabetes Association classification of diabetes mellitus with 1985 WHO classification.Lancet.1998; 352: 1012-1015View in Article
-
- Barrett-Connor E.
- Ferrara A.
Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men: the rancho bernardo study.Diabetes Care.1998; 21: 1236-1239View in Article
-
- Joung K.H.
- Ju S.H.
- Kim J.M.
- Choung S.
- Lee J.M.
- Park K.S.
- et al.
Clinical implications of using post-challenge plasma glucose levels for early diagnosis of type 2 diabetes mellitus in older individuals.Diabetes Metab J.2018; 42: 147-154View in Article
-
- Saramies J.
- Koiranen M.
- Auvinen J.
- Uusitalo H.
- Hussi E.
- Cederberg H.
- et al.
22-year trends in dysglycemia and body mass index: a population-based cohort study in savitaipale.Finland Prim Care Diabetes.2021; 15: 977-984View in Article
-
- Schwarz P.
- Li J.
- Lindstrom J.
- Tuomilehto J.
Tools for predicting the risk of type 2 diabetes in daily practice.Horm Metab Res.2009; 41: 86-97View in Article
-
- Zhang Y.
- Hu G.
- Zhang L.
- Mayo R.
- Chen L.
A novel testing model for opportunistic screening of pre-diabetes and diabetes among U.S. adults.PLoS One.2015; 10e0120382View in Article
-
- Saaristo T.
- Peltonen M.
- Lindström J.
- Saarikoski L.
- Sundvall J.
- Eriksson J.G.
- et al.
Cross-sectional evaluation of the finnish diabetes risk score: a tool to identify undetected type 2 diabetes, abnormal glucose tolerance and metabolic syndrome.Diab Vasc Dis Res.2005; 2: 67-72View in Article
-
- Bahijri S.
- Al-Raddadi R.
- Ajabnoor G.
- Jambi H.
- Al Ahmadi J.
- Borai A.
- et al.
Dysglycemia risk score in Saudi Arabia: a tool to identify people at high future risk of developing type 2 diabetes.J Diabetes Investig.2020; 11: 844-855View in Article
-
- Campos M.A.A.
- Reichelt A.A.J.
- Façanha C.
- Forti A.C.
- Schmidt M.I.
Evaluation of a 1-h 75-g oral glucose tolerance test in the diagnosis of gestational diabetes.Braz J Med Biol Res.2008; 41: 684-688View in Article
-
- Barbosa M.
- Moreira Gomes P.
- Monteiro A.M.
- Matos C.
- Lopes Pereira M.
- Fernandes V.
Postpartum reclassification test in gestational diabetes: can the test be reduced to 1 hour?.Hormones.2022; 21: 287-293View in Article
-
- de Sanctis V.
- Soliman A.
- Tzoulis P.
- Daar S.
- Pozzobon G.C.
- Kattamis C.
A study of isolated hyperglycemia (Blood glucose ≥155 mg/dl) at 1-hour of oral glucose tolerance test (OGTT) in patients with β-transfusion dependent thalassemia (β-TDT) followed for 12 years.Acta Biomed.2021; 92([This retrospective study demonstrated that an isolated high 1-hour post-load glucose level (≥155 mg/dL; H-NGT) during the OGTT may serve as a simple biomarker to detect high-risk patients, with chronic liver disease and/or iron overload, who need periodic glycemic surveillance])e2021322View in Article
-
- Di Bonito P.
- Valerio G.
- Licenziati M.R.
- Corica D.
- Wasniewska M.
- Di Sessa A.
- et al.
One-Hour Post-Load Plasma Glucose and Altered Glucometabolic Profile in Youths with Overweight or Obesity.Int J Environ Res Public Health.2023; 20([The results confirmed and extended the findings of previous studies about the use of one-hour post-load glucose in identifying children and adolescents with isolated IGT and metabolic abnormalities. An elevated one-hour post-load plasma glucose level, not measured with current diagnostic standards, may provide an opportunity for the early identification of a large population despite normal levels of fasting glucose and HbA1c. The finding of an elevated one-hour post-load plasma glucose level can allow lifestyle intervention that has the greatest benefit for preserving or reversing β-cell function and preventing further progression to prediabetes and diabetes]): 5961View in Article
-
- Jagannathan R.
- Stefanovski D.
- Smiley D.D.
- Oladejo O.
- Cotten L.F.
- Umpierrez G.
- et al.
1-h Glucose During Oral Glucose Tolerance Test Predicts Hyperglycemia Relapse-Free Survival in Obese Black Patients With Hyperglycemic Crises.Front Endocrinol.2022; 13([One-hour PG at the time of remission is a better predictor of hyperglycemia relapse than traditional glycemic markers among obese Black patients presenting with DKA/severe hyperglycemia. Testing 1-h PG at insulin discontinuation identifies individuals at high risk of developing hyperglycemia relapse])871965View in Article
-
- Jalleh R.J.
- Xie C.
- Deane A.M.
- Plummer M.P.
- Jones K.L.
- Horowitz M.
- et al.
One-hour plasma glucose level after a 75 g oral glucose load and its relationship to gastric emptying in survivors of critical illness and stress hyperglycaemia.Crit Care Resusc.2022; 24([Glucose intolerance, when defined as 1-hour glucose level ≥ 8.6 mmol/L following a 75 g oral glucose load, persists at 3 months in most survivors of stress hyperglycaemia and is dependent on the rate of gastric emptying. Longitudinal studies to characterise mechanisms underlying dysglycaemia and progression to diabetes in individuals with stress hyperglycaemia are indicated]): 268-271View in Article
-
- Kılınç S.
- Demirbaş T.
- Atay E.
- Ceran Ö.
- Atay Z.
Elevated 1-h post-load plasma glucose levels in normal glucose tolerance children with obesity is associated with early carotid atherosclerosis.Obes Res Clin Pract.2020; 14([As compared with NGT individuals with a 1-h PG <155mg/dL, NGT individuals with a 1-h PG ≥155mg/dL exhibited higher carotid IMT (0.75±0.15mm vs. 0.68±0.15mm; p<0.05). No significant differences were observed in carotid IMT between IGT and NGT subjects with a 1-h PG ≥155mg/dL (0.75±0.18mm vs 0.75±0.15mm; p>0.05). Of the three glycemic parameters, 1-h and 2-h PG, but not fasting glucose, were significantly correlated with carotid IMT. There were no significant differences for increased risk of having NAFLD between the three groups. These data suggest that a value of 1-h PG ≥155mg/dL in children and adolescents with obesity is as important as IGT with respect to cardiovascular risk]): 136-141View in Article
-
- Massimino M.
- Monea G.
- Marinaro G.
- Rubino M.
- Mancuso E.
- Mannino G.C.
- et al.
The Triglycerides and Glucose (TyG) Index Is Associated with 1-Hour Glucose Levels during an OGTT.Int J Environ Res Public Health.2023; 20([The study demonstrated that the TyG index, an efficient and cost-effective marker of insulin resistance, is associated with the variability of early post-challenge glucose levels and is an independent marker of being NGT-1h-high]): 787View in Article
-
- Mogoi M.
- Pop L.L.
- Dediu M.
- Ciuca I.M.
Oral glucose tolerance test in patients with cystic fibrosis compared to the overweight and obese: a different approach in understanding the results.Children.2022; 9([Late peak glucose and 1 h glucose level ≥ 155 mg/dL during OGTT can be used for diagnosing the early glucose metabolism alteration in children with CF]): 533View in Article
-
- Ozgu-Erdinc A.S.
- Iskender C.
- Uygur D.
- Oksuzoglu A.
- Seckin K.D.
- Yeral M.I.
- et al.
One-hour versus two-hour postprandial blood glucose measurement in women with gestational diabetes mellitus: which is more predictive?.Endocrine.2016; 52([Postprandial 1-h and postprandial 2-h plasma glucose measurements were not superior to each other in predicting fetal macrosomia or perinatal complications. Based on our findings, it can be concluded that both methods may be suitable for follow-up as there are no clear advantages of one measurement over the other]): 561-570View in Article
-
- Poon S.W.-Y.
- Tung J.Y.-L.
Thirty-minute post-load glucose could be a useful screening measure for abnormal oral glucose tolerance test response in adolescents with obesity.J Obes Metab Syndr.2022; 31([Addition of 30-minute PG to non-fasting parameters improved the clinical utility in identifying high-risk individuals for abnormal OGTT response]): 272-276View in Article
-
- Popovic D.S.
- Papanas N.
1 h post-load plasma glucose: Should it be re-examined as a diagnostic criterion of diabetes?.Prim Care Diabetes.2021; 15([According to the current American Diabetes Association guidelines, diagnosis of both prediabetes and diabetes in asymptomatic individuals is based on the measurements of fasting plasma glucose (FPG), 2-h plasma glucose (2-h PG) during a 75-g oral glucose tolerance test (OGTT), and glycated haemoglobin (HbA1c) [1]. Pre-diabetes is intermediate glucose metabolism abnormality, encompassing impaired fasting glucose (IFG), impaired glucose tolerance, and borderline HbA1c. Moreover, 1-h plasma glucose (1-h PG) during OGTT is used exclusively for diagnosing gestational diabetes. Forty years ago, 1-h PG was abandoned as diagnostic criterion for dysglycemia, primarily due to fact that it has been proven as a less sensitive and specific indicator of diabetes presence in comparison to 2-h PG. However, at that time, the election between these two criteria was not based on their ability to predict the risk of diabetic complications, which was scrutinised in the study demonstrating that 1-h PG is equally useful to 2-h PG in the prediction of retinopathy risk. Nevertheless, accumulating evidence indicates that 1-h PG ≥ 8.6 mmol/l in individuals with normal glucose tolerance (NGT) is highly predictive of progression to type 2 diabetes, microvascular and macrovascular complications, and mortality. Hence, a group of experts have united in advocating replacement of current OGTT criteria for pre-diabetes. The repercussion of this initiative is more frequent sampling of 1-h PG during the assessment of glucose tolerance. However, this trend raises one important practical question: How shall we correctly interpret the significantly elevated 1-h PG (e.g. ≥11.1 mmol/l) in individuals not diagnosed with diabetes, especially among those classified as having prediabetes defined by the presence of IFG and/or borderline HbA1c, or among those characterised as having NGT?. Available data on the potential specific cut-off value of 1-h PG for diagnosing diabetes is sparse. The aforementioned study has reported that 1-h PG ≥ 12.8 mmol/l may be a threshold for diabetes diagnosis, given that it has almost identical sensitivity and specificity for retinopathy as 2-h PG ≥ 11.1 mmol/l. Furthermore, in the EUROASPIRE IV trial including coronary artery disease patients without previous history of diabetes, the cut-off value of 1 h-PG ≥12.0 mmol/l has demonstrated balanced sensitivity and specificity for detecting diabetes. Obviously, future studies re-examining the utility of 1-h PG in the timely diagnosis of diabetes, potentially contributing to the reduction of chronic complications, are highly desirable]): 622View in Article
-
- Sasaki N.
- Maeda R.
- Ozono R.
- Nakano Y.
- Higashi Y.
Diversity in the risk of type 2 diabetes associated with age, sex, and 1-h post-load plasma glucose levels in the Japanese population with prediabetes.Diabetes Res Clin Pract.2021; 175([The assessment of age and sex-differences and subdivided prediabetes categories based on FPG and 1-h post-load glucose levels may effectively evaluate the risk of type 2 diabetes, which displays marked diversity])108780View in Article
-
- Wang R.
- Liu X.L.
- Jia X.J.
- Liu Y.
- Lu Q.
one-hour post-load plasma glucose levels are associated with early arterial stiffness in subjects with different glucose tolerance.Diabetes Metab Syndr Obes.2022; 15([The present study demonstrated the presence of early arterial stiffness in diabetes. Elevated 1-hour post-load plasma glucose level is closely related to the change of arterial elasticity in diabetes]): 1537-1542View in Article
-
- Xiong T.
- Zhong C.
- Sun G.
- Zhou X.
- Chen R.
- Li Q.
- et al.
Early maternal circulating alkaline phosphatase with subsequent gestational diabetes mellitus and glucose regulation: a prospective cohort study in China.Endocrine.2019; 65([Each additional 10 U/L ALP level was associated with a 2% higher FBG (p = 0.043) and a 12% higher 1-h PBG (p = 0.004)]): 295-303View in Article